| COD | Workload | Description |
| 313A8-02 | 30 | This course addresses: Approaches, methods and techniques for qualitative research in Psychology; The main theoretical-methodological currents that support qualitative analyses in human sciences investigations; Research methods and procedures for the collection and analysis of different types of research employing the qualitative method. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Education | Master's | Not required |
| Education | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Ethics and Political Philosophy | Master's | Not required |
| Ethics and Political Philosophy | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Metaphysics and Epistemology | Master's | Not required |
| Metaphysics and Epistemology | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Master's | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Education theories and cultures | Seeks to explore the relationship between anthropology, history, philosophy, sociology and education, by discussing political and cultural conditions in education. It brings together theoretical and empirical theories and research, so improving our understanding of the diversity of the human experience in the different processes of development. |
| People and education | It studies education as a process that involves the person's non-development, training and self-training, highlighting its intertwining as health and well-being. It hosts interdisciplinary studies and research that enhance the pedagogical dimension of human experience in its interactions as biological, psychosocial, biographical, cultural aspects of two subjects and subjectivities in contemporary society. |
| Education training, policies and practices | Seeks to explore educational processes in different training settings, from socio-political, historical and cultural perspectives, aiming at a critical analysis of policies, training practices, and educational planning in different contexts. It scrutinizes pedagogical practices in several degrees and types of education, enabling insights for decision making regarding changes in society and in the educational process. |
| Education in Science and Mathematics (ESM) | Studies teaching and learning in Science and Mathematics in different training spaces, using theoretical and methodological contributions related to education through research; epistemologically linked to the domain of language, to inter and transdisciplinarity to science and the nature of being and to the modeling processes in Science and Mathematics, associated with initial and continuing teacher training, in Basic Education and Higher Education. It covers research involving scientific and technological development, scientific literacy and the popularization of Science and Mathematics in formal and non-formal spaces of education. |
| The State and Theories of Justice | This line of research addresses the theoretical and pragmatic aspects of the theories of justice from scholars such as Immanuel Kant, John Rawls and Jürgen Habermas, as well as their different critical and alternative views in communitarian and utilitarian theories. |
| Ethics Principles | This line of research addresses the central issues of Ethics as they have been conceived over time and under the systematic aspect, in view of scholars such as Plato, Aristotle, Kant and others. The relationship between practical and theoretical reason is a central area. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Phenomenology and Hermeneutics | This line of research is intended to analyze the classical theories of knowledge under the perspective of the philosophers of phenomenology, which has been the norm in Europe for almost a century and has representatives all over the world. |
| Philosophy in the Middle Ages | This line of research addresses philosophers of the Middle Ages. |
| Analytic Epistemology | This line of research addresses the fundamental topics of contemporary Epistemology: theories of knowledge, theories of epistemic rationality, skepticism and epistemic paradoxes. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 33310-02 | 30 | This course aims to provide deeper insights into the research carried out in ""Neonatal Intensive Medicine"", especially regarding randomized clinical trials.This course is intended to develop: clinical research involving diagnostic imaging tests; critical analysis of scientific studies involving imaging methods; insights into the application of studies involving diagnostic tests in daily medical practice; insights into the different studies to be performed involving diagnostic imaging tests. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63345-02 | 30 | Clinical recommendations include an analysis of the benefits and disadvantages (risks, costs, discomfort) of an intervention. To adapt the recommendations within the scope of the research, the healthcare professional should consider the current evidence and the underlying judgments. A systematic approach that looks at undergraduate studies and the evaluation of the quality of evidence can effectively contribute to the practice of clinical research. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63338-04 | 60 | Knowing how to read and write a scientific article is an essential task for medical researchers. A good reading practice can contribute to a more critical view of the subject and which points of the elaboration of articles are more important to impart the intended contribution of the research, so that the article genuinely become a well-accepted contribution to the field. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63344-04 | 60 | The focus of this course will be on online resources, data security and backup, antivirus, word processors, spreadsheets, graphic programs, statistics programs and bibliographic reference management.The ability to summarize and analyze a scientific article is such a fundamental task for medical research practices. A good reading practice can contribute to a more critical view of the subject and a critical view to them is important to describe the actual contribution o of research conducted, so that the article genuinely become a well-accepted contribution to the field. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63339-02 | 30 | Understanding the basic concepts of biostatistics is basicl for the planning, collection, evaluation and interpretation of data obtained in health research. Thus, this course aims to equip students to describe and perform basic analysis and present research data. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 193BF-01 | 15 | Basic and advanced theoretical concepts on techniques used in the field of biomedicine. Understand microscopy, multiparametric flow cytometry, Western blotting, ELISA, real-time polymerase chain reaction (qPCR), single cell RNA sequencing (scRNAseq), gene editing: CRISPR-Cas9 . Bioinformatics |
| No offer for current semester |
| Concentration area | Type | Required |
| Cellular and Molecular Biology | Master's | Not required |
| Cellular and Molecular Biology | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| Cell Structure and Metabolism | To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action. |
| Cellular and Molecular Immunology | To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts. |
| Cellular and Molecular Characterization in Microbiology and Parasitology | To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents. |
| Genetics, Genomics and Bioinformatics | To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics. |
| Cellular and Molecular Neurobiology | To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels. |
| Molecular Biology in the Drug/Target Interaction | To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer. |
| COD | Workload | Description |
| 40504-04 | 60 | The topics that will be addressed in this course are: Study of biological phenomena involved in the aging process of living beings; An analysis of the different theories intended to explain aging and the endogenous and exogenous factors affecting this process; Mechanisms for replicative senescence: stochastic mechanisms, signal transduction and regulation of cell proliferation, genetic mechanisms; Experimental models for the study of aging; Genetic factors involved in the process of senescence; Cellular and molecular mechanisms of immunosenescence; Immunological risk; Premature immune aging; Modulation of immunosenescence. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Required |
| Biomedical Gerontology | Doctorate | Required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 33305-04 | 60 | Neonatology is one of the major areas in Pediatrics. It has been one of the major focuses of medical research over the last decades due to the great contribution of the neonatal range to infant mortality and the large number of unresolved issues regarding Diagnosis and treatment. Most research on Neonatology focuses on Neonatal Intensivism. Within the concept of Evidence-Based Medicine, Randomized Clinical Trials have become the main tools for supporting the decision as to the intervention in these high-risk children. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 19301-02 | 30 | This discipline has as main objective the presentation of the main concepts associated with clinical trials. The main advantage of the clinical trial over an observational study is its greater ability to demonstrate the effects of interventions on one or more outcomes. However, the clinical trial often presents a greater demand for time and cost, addresses a specific issue, and may expose participants to potential adverse effects. Therefore, clinical trial studies should carefully develop the methodology so that the evidence can be effective and cause as little harm as possible to the participants. |
| Professors | Home time | Lattes |
| HUMBERTO HOLMER FIORE | 24 years and 3 months | Link |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63341-04 | 60 | The elaboration of a high-quality project is essential for the progress of scientific research. Thus, this course aims to qualify equip students to write and present a project in both clinical and experimental areas by discussing basic concepts of the anatomy and physiology of a research project. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Research line | Description |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| COD | Workload | Description |
| 1933J-02 | 30 | The understanding of the mechanisms involved in the ontogenesis of the central nervous system (CNS) has had a major boost in recent decades with the decrease in neonatal morbidity and mortality. Extreme premature infants survive in the ICU and are followed up clinically. With the advancement of knowledge in the area of Neuroscience, it became essential to know the mechanisms by which neurological diseases and environmental factors affect the brain during its development and its future consequences. The management of newborns with neurological disease differs greatly from the approach used in older children and adults. The pathologies that occur in the different childhood groups (newborn, infant, pre-school, school, adolescent) are mostly age specific, and their prevalence is totally different from that seen in adulthood. The study of the SNC in development is justified in a Neuroscience course because it has a direct application not only in medical practice but also in the design of the most diverse research projects and serves as a basis for the other disciplines offered. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 83278-02 | 30 | To identify the nature of the epidemiological study; to describe different epidemiological methods; to name and characterize the indexes of epidemiological nature related to cavities and periodontal disease; to establish the main interrelations between biological and social indicators with the development of cavities and periodontal disease; to organize epidemiological surveys; to apply epidemiological indices of cavities and periodontal disease; to analyze and interpret the results of epidemiological studies.The course brings the fundamental concepts of Ethics in order to achieve the following goals: the formulation of correct ethical judgments; proper use of ethical principles in individual, family, professional, social and political daily life; understanding and developing the ability to criticize, accept or refuse principles of action in the various aspects of daily life; understanding and searching for solutions to some of the serious problems that defy humanity through applied Ethics. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biology and Orofacial Rehabilitation | Master's | Not required |
| Biology and Orofacial Rehabilitation | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Ontological Clinic | Master's | Not required |
| Ontological Clinic | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| oral biology | Master's | Not required |
| oral biology | Doctorate | Not required |
| Research line | Description |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Etiopathogenesis and Treatment of Periodontal and Periapical Diseases | This line of research aims to study the mechanisms involved in periapical and periodontal alterations, aiming to analyze their relationship with systemic diseases, as well as to identify new treatment strategies for these conditions. |
| Etiopathogenesis and Treatment in Stomatology | The objectives of this line of research involve the evaluation of the pathophysiology of diseases affecting the oral mucosa and salivary glands, including oral cancer, focusing on the clinical, immunological, and pathological aspects of these conditions, in order to identify new forms of prevention and treatment of such diseases. |
| Pediatric Oral Health | This line of research aims to evaluate new approaches to the prevention, diagnosis, and treatment of oral cavity disorders, focusing on the management of pediatric patients. |
| Restorative and Reconstructive Dentistry | This line of research focuses on developing new technologies and approaches aimed at aesthetic and functional oral rehabilitation, using laboratory and clinical assessment methodologies. It also includes new approaches for the orthodontic, orthopedic, and surgical correction of orofacial deformities, seeking to improve the diagnosis and management of patients with these conditions. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Biomechanics, Pain and Orofacial Dysfunction | This line of research is aimed to analyze the pathophysiology of orofacial pain, temporomandibular dysfunction, bruxism and parafunctional habits, focusing on the biomechanical characterization of the stomatognathic system and its reflexes on the organism, seeking to identify new diagnostic and therapeutic strategies for these conditions. |
| Biomaterials and Tissue Engineering | This line of research aims at the development and evaluation of the efficacy and safety of new dental materials, as well as innovative tissue engineering strategies, focusing on tissue regeneration and the reduction of infectious oral complications. |
| Microbiology and Oral Immunology | This line of research aims to develop research with a specific focus on oral microbiology and oral immunology, for diagnostic and therapeutic purposes. |
| COD | Workload | Description |
| 1932B-02 | 30 | Scientific development is a continuous and systematic process of actions aimed at contributing to academic excellence, based on teaching and research. The production of knowledge alone is not enough to consolidate the qualification of graduate students. Dissemination of knowledge is required for the scientific community and society as a whole. The dissemination of new knowledge acquired at our University and the sharing of knowledge globally can only be intensified when they are disseminated in a common peer language, facilitating interaction between teaching and research institutions from different countries. Today, internationalization is mandatory for continued development and scientific recognition. To this end, our graduate students will be required to receive English language training in the dissemination of their productions to the scientific community in international journals, as expected for the excellent graduate programs. |
| Professors | Home time | Lattes |
| DENISE CANTARELLI MACHADO | 27 years and 3 months | Link |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 20500-02 | 30 | The course aims at fostering a critical reflection on the scientific method and its practical use in research. It will address, in a practical way, the concepts of clinical epidemiology and biostatistics by means of their application in research projects developed by graduate students. It will enable the discussion of all elements of a research project, with emphasis on the methods used by each student in their research project. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 63340-02 | 30 | Clinical epidemiology is a basic tool for evidence-based clinical medicine. This course studies clinical events in a specific group of people, using standardized scientific methods, with the purpose of producing accurate and valid information, for a better treatment and prevention of diseases. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 1938D-02 | 30 | Infectious diseases have been a great challenge to human kind, with special burden during the childhood. Despite the important epidemiological changes that occurred during the last decades, this group of diseases is still associated to a significant morbimortality worldwide. The high burden in public health demands from health professionals being able to apply, teach and generate knowledge about the epidemiology, transmission and prevention of infectious diseases. This course aims to offer the student conditions to perform the activities listed above. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 1932C-03 | 45 | The course will provide a comprehensive overview of the most relevant diagnostic imaging modalities used in radiology and nuclear medicine, covering both clinical and technical aspects, throughout an interdisciplinary approach. The course will introduce the physical principles underlying different medical imaging modalities along with examples of specific applications. The basic principles of digital image processing, including common terminology and the components that define image quality will be discussed. The ongoing research and new developments in molecular and hybrid imaging modalities will be discussed. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 63342-02 | 30 | The Master's degree is the first level of a stricto sensu graduate program (GP), whose main objective is to produce professors to teach in higher education, either in colleges or universities. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 19302-02 | 30 | Nowadays, with the free access to knowledge and data through social networks and the Internet, the number of cases of misconduct in research execution and publication around the world is increasing, leading to the loss of the credibility of scientific publications. This course aims to guide students about good research practices, from the projects execution to the results communication and publication, stressing the importance of research data adequate registration. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Required |
| Biochemical and Molecular Pharmacology | Doctorate | Required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Required |
| Medical Practice | Doctorate | Required |
| Nephrology | Master's | Required |
| Nephrology | Doctorate | Required |
| Neurosciences | Master's | Required |
| Neurosciences | Doctorate | Required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Required |
| Surgical Practice | Doctorate | Required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 63350-02 | 30 | The study of important concepts of immune response is applicable in different areas of pediatrics and can contribute to the scientific training of students. Hence, the course may equip students with the tools to discuss articles in pediatrics involving basic immunological aspects. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 1935K-02 | 30 | In graduate courses there is a great need for software tools for knowledge production in the health area. This course offers an introduction to data science, with practical exercises for creating databases, descriptive analysis, reports and graphs using Microsoft Excel and the statistical programming environment R. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63343-02 | 30 | Thus, in addition to the research activities already included as a priority in the GPP curriculum, it is important to produce master¿s/doctoral students for teaching, and to actively participate in the teaching-learning process in Brazilian colleges and universities.New software and updates of established versions are continually offered. The purpose of this course is to share our experiences with software that we believe are important in medical research. We will give you an overview of various programs and some practical experience, through classroom exercises, with the most important software. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63361-02 | 30 | This course aims to introduce students to different types of viruses found in nature and their role in triggering diseases in humans. In addition, the course aims to equip students to understand the pathophysiology of virus diseases and the human immune response triggered by human viruses. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 1938F-02 | 30 | The course aims to explore the epidemiological aspects related to the main population studies focusing on nutrition and maternal and child health. It also aims to identify the interface between research and society, proposing reflection on social inclusion and communication of findings. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63349-02 | 30 | Understanding research designs is fundamental for researchers in the area of Health. In addition, health professionals who read and use new data from international scientific production in their clinical practice should also be familiar with the guidelines for a better understanding and application of evidence-based health practices |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Required |
| Research line | Description |
| COD | Workload | Description |
| 1933I-02 | 30 | The main objective of this course is to provide a comprehensive view of the principles of virology, addressing molecular concepts involving viral replication and the immune response during viral infections. The focus of the course will be viruses that affect the pediatric population. Goals: Train the students in general and specific knowledge of viral infections, focusing on those that mainly affect the pediatric population. Content: General aspects of the viral infections that affect children, concepts such as viral replication and immune response to viral infections, diagnosis of viral infections, treatments and new therapies for controlling viral infections. |
| Professors | Home time | Lattes |
| ANA PAULA DUARTE DE SOUZA | 11 years and 8 months | Link |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 19347-02 | 30 | Explore the concepts of stress, health and disease, with a particular focus on historical and current literature. It will address multiple dimensions in the study of stress: genetics, epigenetics, molecular, cellular, physiological and cognitive, especially in the context of immunoendocrine and neuroscientific research. Study of the individual response to stress, as genetic and environmental factors play a role, as it translates into physiological and mental conditions and pathological or health conditions. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 23394-02 | 30 | This course is intended to address several aspects related to the pharmacology of inflammation, namely: biochemical and molecular aspects of inflammatory events, with emphasis on pharmacological modulation. The main vascular and cellular alterations in response to different stimuli will be addressed. To follow are some topics of interest: (1) study of inflammatory response mediators, including those derived from mastocytes (histamine and serotonin), lipid mediators (prostanoids and leukotrienes), peptidic mediators (bradikinin and neurokinin), cytocines and growth factors, chemotactic factors, complement system mediators, nitric oxide, among others; (2) components of the resolution phase of inflammation, involving endogenous mediators related to the re-establishment of homeostasis and tissue repair; (3) main groups of cells involved in several phases of inflammation and their connection to immune response; (4) main receptors and signaling routes, as well as the components of intracellular transduction systems; (5) inflammation associated with infection and systemic inflammatory response; (6) correlation between inflammation and cancer; (7) regulatory aspects of the transcription of molecules implied in inflammatory response; (8) study of mechanisms of action of main drugs used in the treatment of inflammation; (9) chronic inflammatory diseases. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 1932A-01 | 15 | Neuropharmacology is the study of the effect of drugs on the brain. The seminars explore the concepts and current research in cognitive neuroscience, including perception, brain structure and organization, cognition, memory and the functional basis of certain human neurological and psychiatric illnesses. (e.g. schizophrenia, depression and Narcolepsy). The purpose of this course is to provide students with an opportunity to acquire the theoretical and applied knowledge of neuropharmacology that will enable them to proceed into developing a career in neuropharmacology either in an academic institution, a research institute or in the industrial/business sector. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| Cellular and Molecular Biology | Master's | Not required |
| Cellular and Molecular Biology | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Pharmaceutical Biotechnology | Professional Master's | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Cell Structure and Metabolism | To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action. |
| Cellular and Molecular Immunology | To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts. |
| Cellular and Molecular Characterization in Microbiology and Parasitology | To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents. |
| Genetics, Genomics and Bioinformatics | To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics. |
| Cellular and Molecular Neurobiology | To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels. |
| Molecular Biology in the Drug/Target Interaction | To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 193BJ-02 | 30 | The discipline of Physical Activity in Pediatrics proposes a training focused on the evaluation and intervention through physical activity and exercise in chronic pathologies in childhood. During the sessions, concepts of physical activity and exercise, principles of exercise physiology, evaluation of physical activity and exercise capacity, and characteristics of pediatric rehabilitation programs will be addressed. These contents review key aspects for a comprehensive approach that trains students in the design and application of exercise programs in the main chronic pathologies in childhood. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63348-04 | 60 | Knowing how to use computer tools is fundamental for conducting research in health. This course is intended to explore, in a practical way, important software for medical research. The focus will be on online resources, spreadsheets, graphic programs, statistical programs, word processors, and bibliographic reference management. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Cellular and Molecular Biology | Master's | Not required |
| Cellular and Molecular Biology | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Cell Structure and Metabolism | To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action. |
| Cellular and Molecular Immunology | To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts. |
| Cellular and Molecular Characterization in Microbiology and Parasitology | To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents. |
| Genetics, Genomics and Bioinformatics | To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics. |
| Cellular and Molecular Neurobiology | To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels. |
| Molecular Biology in the Drug/Target Interaction | To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 63416-02 | 30 | This course is intended to introduce students to the main theoretical and practical concepts of the area of molecular biology, applied to the health area, focusing on the main current scientific topics of molecular biology therapies. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Cellular and Molecular Biology | Master's | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Cell Structure and Metabolism | To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action. |
| Cellular and Molecular Immunology | To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts. |
| Cellular and Molecular Characterization in Microbiology and Parasitology | To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents. |
| Genetics, Genomics and Bioinformatics | To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics. |
| Cellular and Molecular Neurobiology | To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels. |
| Molecular Biology in the Drug/Target Interaction | To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 63346-02 | 30 | This course is intended to improve the theoretical and practical bases for the development of research projects in Pediatrics. |
| Professors | Home time | Lattes |
| RENATO TETELBOM STEIN | 38 years and 8 months | Link |
| Concentration area | Type | Required |
| Pediatrics | Master's | Required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 31356-02 | 30 | This course addresses basic and applied research regarding the psychobiological and molecular aspects of mental disorders. It also discusses cognitive neuroscience of mental disorders. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Master's | Not required |
| Psychology | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 7334J-01 | 15 | Designing and adhering to the appropriate methodology is fundamental for improving the quality of research. The methodology may differ from problem to problem, yet the basic approach towards research remains the same. |
| Professors | Home time | Lattes |
| FREDERICO ORLANDO FRIEDRICH | 2 years and 2 months | Link |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 33350-02 | 30 | This course is intended to develop: clinical research involving diagnostic imaging tests; insights into the practical application of results of studies involving diagnostic tests can be used in daily medical practice. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63351-04 | 60 | The use of experimental models has allowed for important advances in the diagnosis and treatment of numerous diseases. Thus, the expertise of health professionals regarding the interpretation of results from experimental research, its applicability, limitations and ethical aspects, are of fundamental importance. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 63362-02 | 30 | This course is intended to get students acquainted to the different mechanisms of activation of inflammatory response and how this response impacts the pathogenesis of several respiratory diseases. Besides, the course provides students with deeper insights into how to design highly impacting scientific articles on inflammation and respiratory diseases. |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 1938E-02 | 30 | The speed and disseminated access to information nowadays, associated with the COVID-19 pandemic, have increased the need for adequate communication between professors or researchers and the general public through various platforms. In addition to the skills intrinsically necessary for academic work, the skills that prepare professionals for active participation in the media must be properly trained, avoiding the isolation of knowledge producers and leaving the general population receiving only information from unreliable sources. The purpose of the course is to prepare the graduate student to prepare lectures, interviews and management of social media. |
| Professors | Home time | Lattes |
| MARCELO COMERLATO SCOTTA | 13 years and 4 months | Link |
| Concentration area | Type | Required |
| Communication Practices and Culture | Master's | Not required |
| Communication Practices and Culture | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 7311B-02 | 30 | This course intends to foster discussions on research policies in Brazil, including the assessment criteria employed by CAPES as well as scientometrics criteria. It also discusses the means for obtaining funding for scientific projects with an eye to meeting the different criteria set forth in specific projects. Additionally, one of the goals of the course is to discuss the scientific career both in Brazil and overseas and the possibilities for getting into the market. The course will discuss the differences between the areas of concentration as well as regional differences and other controversial topics in science. The peer-review process will be addressed, for both projects and scientific papers submitted to indexed journals. Part of the classes will be devoted for discussions on the ethical aspects of research, including issues such as plagiarism, co-authorship, publication of negative results, among others. Students will receive specific training to properly advise final papers as well as theses and dissertations. |
| No offer for current semester |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Cellular and Molecular Biology | Master's | Not required |
| Cellular and Molecular Biology | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Ecology and Evolution of Biodiversity | Master's | Not required |
| Ecology and Evolution of Biodiversity | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Cell Structure and Metabolism | To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action. |
| Cellular and Molecular Immunology | To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts. |
| Cellular and Molecular Characterization in Microbiology and Parasitology | To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents. |
| Genetics, Genomics and Bioinformatics | To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics. |
| Cellular and Molecular Neurobiology | To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels. |
| Molecular Biology in the Drug/Target Interaction | To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer. |
| Ecology and Conservation | This line of research encompasses projects focusing on ecological relationships among organisms and with their environment, including studies of autecology, ecophysiology, behavior, population dynamics and community ecology, as well as projects aiming to provide scientific bases for biodiversity conservation strategies. |
| Systematics and Evolution | The research line brings together projects related to the evolution of biodiversity, including studies in phylogenetic systematics (using morphological and molecular data, including phylogenomics), taxonomy, comparative morphology, biogeography, evolutionary genetics, and comparative genomics. |
| The research line brings together projects focused on the use of large amounts of information ('big data') and the development of innovative data mining and analysis methodologies (e.g., employing machine learning) to investigate issues related to the characterization, monitoring, and conservation of biodiversity | |
| The research line encompasses projects aimed at applying ecological data, biodiversity component analyses, and/or interdisciplinary studies to solve problems with more direct socio-environmental and/or economic impact. This includes studies in the fields of ecotoxicology and environmental microbiology with a focus on the characterization, monitoring, and mitigation of environmental impacts, as well as the development of more sustainable agricultural methods using components of Brazil's native biodiversity. It also includes projects aimed at developing innovative products from biodiversity sources and/or integrating biodiversity analyses into regional economic development models with a focus on environmental sustainability. | |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 33351-02 | 30 | Graduate students generally have little experience in writing scientific articles and regarding the publishing process. After completing the course, most professionals face significant difficulty when writing scientific articles. For those who will work in the field of research, scientific production is one of the central aspects for professional success. Based on this premise, it is important that graduate courses offer a course that introduces and provides deeper insights into theoretical and practical bases for writing scientific articles. |
| Professors | Home time | Lattes |
| FREDERICO ORLANDO FRIEDRICH | 2 years and 2 months | Link |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Cellular and Molecular Biology | Master's | Not required |
| Cellular and Molecular Biology | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Inter-institutional doctorate degree | Required |
| Pediatrics | Doctorate | Required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Cell Structure and Metabolism | To follow is a list of topics this line of research is concerned with: Characterization of plant growth-promoting rhizobacteria (PGPR) and their effects on the growth and modulation of plants' secondary metabolism. Investigation into the morphological and pathophysiological basis and treatment for several diseases, such as Parkinson's and Alzheimer's, vascular accidents, depression, PTSD, epilepsy and diabetes. Characterization of the cellular and molecular mechanisms involved in inflammation and sepsis and investigation into drugs with potential anti-inflammatory action. |
| Cellular and Molecular Immunology | To follow is a list of topics this line of research is concerned with: Development of vaccines and immunotherapies for cancer. Study of the immunosuppressive mechanisms using heat shock proteins in autoimmune diseases and transplant rejection. Investigation of psycho-neuroendocrine determinants of premature aging and immune system in healthy elderly individuals, patients with rheumatoid arthritis and bipolar disorder. Investigation into the impacts of premature stress in cognitive functions and inflammatory markers in healthy adolescents, those with bipolar disorder, and crack and cocaine addicts. |
| Cellular and Molecular Characterization in Microbiology and Parasitology | To follow is a list of topics this line of research is concerned with: Development of new diagnostic methods for Schistosoma mansoni and Angiostrongylus cantonensis. Identification of relevant molecules involved in the immunological recognition of the host and ectoparasites, such as Rhipicephalus microplus and others affecting cattle. Isolation, cloning and expression of cDNAs of molecules and analysis of their potential immunoprotective effect. Characterization of antimicrobial resistance, virulence and clonal relations of important human and animal pathogenic agents. Investigation of phenotypes of bacterial persistence involved in the tolerance to antimicrobial agents. |
| Genetics, Genomics and Bioinformatics | To follow is a list of topics this line of research is concerned with: Analysis of molecular markers in complex human diseases and analysis of molecular markers for forensic purposes. Phylogeny and molecular evolution of mammals. Genetics, evolution, ecology and conservation of carnivores. Evolutionary genetics of hair color of felidae. Molecular identification of biodiversity. Evolutionary and environmental genomics. |
| Cellular and Molecular Neurobiology | To follow is a list of topics this line of research is concerned with: Animal models (zebra fish and rodents) intended to investigate the biological bases of neuropsychiatric diseases, neurodevelopment, neurotoxicology, neuropharmacology, learning and memory. In humans: aging and neurodegeneration, cognitive impairment and its association with hormone and neurotrophin levels. |
| Molecular Biology in the Drug/Target Interaction | To follow is a list of topics this line of research is concerned with: Control and treatment of tuberculosis (drug-resistant tuberculosis) Identification of lead compounds based on defined targets, rational development of vaccines, development and validation on new diagnostic methods of multi-drug-resistant tuberculosis and new emerging genotypes. Additionally, students will make use of computer simulations in order to analyze the protein-ligand interactions. As well as this, it will address the structural study of target proteins, analysis of protein-ligand interactions and the development of bioinformatics tools. Lastly, it will focus on a description of mechanisms involved in pain, inflammation and cancer. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 1933F-02 | 30 | Understanding the basic concepts of how to select appropriate instruments for data collection is essential for the development of research projects. Thus, this course aims to qualify the student in basic concepts regarding the assessment, adaptation and validation of instruments in research. |
| Professors | Home time | Lattes |
| THIAGO WENDT VIOLA | 4 years and 8 months | Link |
| Concentration area | Type | Required |
| Biochemical and Molecular Pharmacology | Master's | Not required |
| Biochemical and Molecular Pharmacology | Doctorate | Not required |
| Biomedical Gerontology | Master's | Not required |
| Biomedical Gerontology | Doctorate | Not required |
| CTBMF | Master's | Not required |
| CTBMF | Doctorate | Not required |
| Clinical Psychology | Master's | Not required |
| Clinical Psychology | Doctorate | Not required |
| Clinical Stomatology | Master's | Not required |
| Clinical Stomatology | Doctorate | Not required |
| Dental Materials | Master's | Not required |
| Dental Materials | Doctorate | Not required |
| Dental Prosthetics | Master's | Not required |
| Dental Prosthetics | Doctorate | Not required |
| Endodontics | Master's | Not required |
| Endodontics | Doctorate | Not required |
| Human Cognition | Master's | Not required |
| Human Cognition | Doctorate | Not required |
| Medical Practice | Master's | Not required |
| Medical Practice | Doctorate | Not required |
| Nephrology | Master's | Not required |
| Nephrology | Doctorate | Not required |
| Neurosciences | Master's | Not required |
| Neurosciences | Doctorate | Not required |
| Orthodontics and Facial Orthopedics | Master's | Not required |
| Orthodontics and Facial Orthopedics | Doctorate | Not required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Psychology | Doctorate | Not required |
| Restorative Dentistry | Master's | Not required |
| Restorative Dentistry | Doctorate | Not required |
| Social Psychology | Master's | Not required |
| Social Psychology | Doctorate | Not required |
| Surgical Practice | Master's | Not required |
| Surgical Practice | Doctorate | Not required |
| Research line | Description |
| Evaluation of mechanisms involved in inflammatory and nociceptive alterations | This line of research is concerned with the evaluation of mechanisms involved in inflammatory and nociceptive alterations |
| Drug Development | This line of research has been designed for the development of drugs against neglected tropical diseases (tuberculosis and malaria) and the development of drugs against chronic and degenerative diseases. |
| Evaluation of pharmacological targets in cancer treatment | This line of research is concerned with the evaluation of pharmacological targets in cancer treatment and inflammation. |
| Analysis and evaluation of neurochemical and pharmacological mechanisms in neurological diseases | Study of the neurochemical roots and pharmacological targets in neurological diseases. |
| Biological Aspects of Aging | This line of research is intended for the study of basic biological characteristics that play a role in the process of aging at the molecular, cellular, biochemical, genetic and evolutionary levels, as well as their forms of interaction with environmental factors in animal models and human beings (in vitro and in vivo). |
| Clinical and Emotional Aspects of Aging | This line is geared towards the clinical and epidemiological study of the elderly and aging. Some of the most commonly researched topics are: geriatric syndromes (cognitive impairment, postural instability, immobility, fecal incontinence, iatrogenesis, communication disorder), frailty syndrome, brain aging, mental health, osteomuscular aging, cardiometabolic risk factors and nutrition. |
| Social-cultural, Demographic and Bioethical Aspects of Aging | This line is geared towards the study of social, cultural, economic, demographic and bioethical aspects involved in the process of aging. |
| Aging and Public Health | This line of research is intended to study the conditions of life, health and health care received and provided to the elderly, including long-living patients. It is intended to assess primary and secondary health care services, to design of instruments for monitoring access, service routines and care provided to the elderly and long-living patients in the public health care network. Additionally, it will investigate the natural history of diseases and health conditions as well as health prevention and control, in view of the socio-demographic variables, health indicators, life styles, functional capacity, psycho-social competences and quality of life. |
| Extra-renal dialysis and transplatation | This line of research is intended for the study of different modalities of renal replacement therapies, with emphasis on organ transplantation, especially when it comes to immunology of transplants. |
| Clinical nephrology and arterial hypertension | This line of research will address topics related to several aspects of clinical nephrology, renal function, arterial hypertension, renal and metabolic diseases. |
| Molecular Biology, immunology and stem cell | This line of research is concerned with the study of molecular alterations in tumors, mainly those affecting the digestive and respiratory systems, through PCR techniques in real time, immunohistochemistry, flow cytometry and cell cultivation. It will also look at Cell Therapy and Tissue Engineering. |
| Cardiology/Risk Factors and genetics factors in cardiovascular diseases | This line of research is concerned with assessing risk factors for cardiovascular surgeries using markers; traditional risk factors (dyslipidemias, arterial hypertension, diabetes, smoke addiction) and potential emerging ones (apolipoprotein B,small and dense LDL cholesterol) in coronary heart diseases. |
| Cardiology/Cellular therapy | This line of research is intended to assess the efficiency and safety of autologous implants of bone marrow stem cells in patients suffering from dilated cardiomyopathy and in patients suffering from acute myocardial infarction. |
| Cellular metabolism and membrane transport in renal and metabolic diseases (or disease states) | This line of research is designed for the study of physiopathogenic mechanisms of several renal and metabolic diseases. |
| Training and Faculty Development in Health | |
| Study abdomen adult and elderly healthy and sick with new technologies in Diagnostic Imaging | First of all, this line of research is intended to introduce students to different abdominal organs in advanced imaging modalities, such as magnetic resonance and positron emission tomography. It is intended to study the normal anatomy of these organs and tissues and their anatomic variations, thus allowing for a comparison between healthy and unhealthy individuals. With this, we intent to provide deeper insights into the abdomen's normal anatomy and its anatomic variation through new imaging technologies. Additionally, this line of research will determine the diagnostic imaging accuracy of gastrointestinal tract and urinary system diseases. We are intent on reaching an earlier and more precise diagnosis of the diseases of adult and elderly patients, thus increasing their survival. It has been designed to produce researchers and professors who want to work within this line of research responsible for studying the most common diseases in our population. |
| Clinical Epidemiology | This area of concentration is intended to develop research in clinical epidemiology focusing on its methodological and clinical aspects. This line of research intends to encourage the development of research projects that contribute to the progress in identification, intervention and promotion of determinants of the health-disease process in human population. |
| Functional and Molecular Image of the Body | Functional imaging is the state-of-the-art in diagnostic imaging. Magnetic Resonance made a giant leap in that direction through the employment of ultra-rapid acquisition techniques, which have enabled the measurement of variations in oxygen consumption levels arising from the BOLD effect and an estimation of the cellularity of tissues through the diffusion technique. PET has enabled Nuclear Medicine to measure the level of consumption of glucose in the tissue, by making use of ionizing radiation. It is largely employed in the investigation of tumors and metastasis, which have naturally increased the consumption of glucose due to a larger metabolic level. More recently, the Dynamic PET has enabled the assessment of the consumption of glucose over time and the measurement of the most active regions more precisely. |
| Epidemiology and Environmental Health | This course is intended to encourage the development of research into the area of epidemiology and environmental health with an eye to the methodological and clinical aspects. This line of research seeks to encourage the development of research projects that contribute to the advancement of the identification, intervention and promotion of the determinants of the health-disease process in human population. |
| Technological Innovations in the Health Area | Curently, we are seeing worldwide the fast development of technologies, proceedings and medicines focus at the most effective treatment of diseases and the restoration of health. This accelerated step with which medical knowledge progresses makes it necessary to create a new mentality in medical training, stimulating curiosity, the active search for knowledge and constant updating. The number and complexity of the scientific processes that lead to this evolution are also worthy of attention, both due to the need for training to understand them, as well as the work opportunity they represent for doctors in general. |
| Neurology/ stem cells | This line of research is concerned with the assessment of the possibility of regeneration of central and peripheral neurological injuries resulting from neurodegenerative diseases, with somatic stem cells, as well as with the study of the structural and functional mechanisms of regeneration from injuries. |
| Behavioral neurology and neuropsychiatry | This line of research will look at the neurobiology of psychiatric diseases and behavioral alterations in major neurological diseases. |
| Cognitive brain imaging | This line of research will look at the development of new techniques for the analysis of neuroimaging and studies of neural bases of superior cognitive processes (for instance, language comprehension and acquisition, executive functions, spatial reasoning). |
| Neurotoxic activity of ureases and derived peptides | This line of research will address the neurotoxic and pro-inflammatory activities of ureases of different organisms. It will also address the methodologies of study of neurotoxicity relying on the use of insects-models. As well as this, it will look at ureases as virulence factors for pathogenic microorganisms, especially bacteria Helicobacter pylori and Proteus mirabilis and Cryptococcu yeasts. |
| Neuroinflammation/Multiple Sclerosis/ neuromyelitis optica | The inflammation resulting from neurological diseases may be primarily involved with the physiopathology of immunomediated diseases of the nervous system, such as multiple sclerosis, neuromyelitis optica, ADEM - acute demyelinating encephalomyelitis, Guillain-Barré syndrome, autoimmune encephalitis and some neurological complications resulting directly or indirectly from viral or bacterial infections (e.g. meningoencephalitis). In other diseases, the inflammation plays a major role, but less clear than it is in strokes and in degenerative diseases of the central nervous system. The deregulation in the immune system, be it either temporary or permanent, may lead to injuries in the brain, bone marrow and peripheral nerves that cause permanent neuronal damage with the risk of aftereffects and permanent incapacity. By relying on advanced methods in molecular biology associated with clinical and imaging assessment (magnetic resonance, nuclear medicine), we have conducted research that is intended to understand the intrinsic and extrinsic mechanisms that lead to an increase of pro-inflammatory substances such as cytokines, chemokines, the production of autoantibodies, complement system activation, proliferation / maturation of autoreactive lymphocytes T and B, microglial activation and the alteration of the blood-brain barrier. Besides, we have conducted research for the identification of specific biomarkers for each disease which may assist in the establishment of better diagnosis/prognosis and in experimental animal models for the study of physiopathology and innovative therapeutic interventions. |
| Epilepsy | This line of research will cover clinical and electroencephalographic, pharmacological, neuroimaging and surgical studies in the realm of epilepsy. The direct involvement of São Lucas Hospital with the diagnosis, clinical treatment and epilepsy surgery opens interesting perspectives of investigation, seeking diagnostic refinement, new treatment options and the correlations of epileptic syndromes with structural alterations of the brain. |
| The central nervous system (CNS) formation stages can be considered a great concert with the regency of different signaling molecules that trigger a cascade of dependent and complementary processes until the formation of all CNS structures as well as their different functionalities. The human brain is a puzzle of more than 100 billion pieces that must be accurately directed to its unique and specific location. The studies of Molecurar Bases of Embryonic Neurogenesis presents a comprehensive view of understanding the CNS, from its embryonic formation to neurogenesis in the adult brain, guiding clinical and pathological situations related to cerebral malformations and new therapeutic alternatives for CNS recovery. The use of molecular techniques as next-generation sequencing (NGS), super arrays, relative expression, genotyping, etc., are used to describe signaling pathways, genesis of pathologies, and application of precision medicine for the treatment of various diseases. The cell reprogramming at the embryonic level through the generation of induced pluripotent stem cells (iPSC) helps to understand embryonic neurogenesis and screening of new drugs for the treatment of alterations during the formation of the central nervous system and its associated pathologies | |
| Artificial Intelligence in Healthcare | Fluency in oral reading is a crucial skill for children and adolescents, involving the ability to read a text with accuracy, appropriate expression, and at a determined pace. Artificial intelligence has enabled considerable advances in activities that previously required time and attention from specialized professionals, also offering the advantage of impartial evaluation. Moreover, a significant portion of students in Brazil presents literacy difficulties associated with reading skills and lacks adequate assistance and diagnosis for conditions such as dyslexia. This research line aims to encompass research projects at the intersection of health, education, and artificial intelligence. The studies seek to investigate tools for assessing oral reading through innovative technologies, which can be used by health professionals in collaboration with educators. These tools aim to assist in identifying the level of reading development, factors influencing these skills, association with academic performance, early screening of signs of difficulties and disorders affecting reading fluency, differential diagnoses, as well as the appropriate medical/educational conduct. |
| Assessment and psychological interventions in mental health | This line of research concentrates studies related to mental health outcomes based on different theories and methods in Clinical Psychology. It aims at understanding psychological processes and building and adapting instruments and interventions with a psychotherapeutic and psychoeducational focus. |
| Psychosocial Processes: Practices and contexts | This line of research concentrates studies on psychosocial phenomena and vulnerability processes in different contexts, such as education, public health, work, politics and justice. It aims to develop strategies for assessment and intervention with individuals, groups and organizations based on theoretical-methodological approaches that articulate different perspectives from Social Psychology and other fields of knowledge. |
| Cognition, brain and behavior | This line of research focuses on basic and applied studies of cognition and its behavioral and neurobiological implications. We seek to investigate neurocognitive and psychobiological processes and their relationship with behavior, development, learning and mental health. Research approaches involve theoretical and experimental models and instruments from neuropsychology, neurobiology and neuroscience. |
| Well-being, health and quality of life | This line of research concentrates studies that use an interdisciplinary approach on the relationship between mental health and lifestyle, understood as the set of behaviors related to food, physical activity, sleep, spirituality, financial well-being, well-being occupational and social relationships. The line aims at building basic and applied knowledge for evaluation and intervention in the prevention and promotion of quality of life and its different domains. |
| Obesity and Metabolic Syndrome | This line is concerned with research in the area of obesity and metabolic syndrome with consequences in co-morbidities involved or related to the aforementioned pathologies. |
| Epidemiological, Clinicopathological, Radiological and Molecular aspects of malignant neoplasms. | This area of concentration is intended to describe patients who suffer from malignant neoplasms in their different clinical stages, as well as to assess their clinical outcome by looking at the clinical, histopathological, radiological and molecular variables. Studies in this area may be accountable for addressing some issues that are still controversial among the scientific community. |
| Videolaparoscopic Surgery | This area of concentration is intended to assess the advantages of the procedures conducted using less invasive techniques. |
| COD | Workload | Description |
| 1933D-02 | 30 | The study of the ontogeny of sleep through the evaluation of clinical and neurophysiological features forms the basis for the understanding of sleep medicine. Sleep medicine is considered one of the newest medical specialties and its main feature is the multi-disciplinarity. Many health professionals and medical specialists are involved in the evaluation of sleep disorders as neurologists, pediatricians, pulmonologists, otorhinolaryngologists, clinicians, surgeons, psychiatrists, dentists. Sleep disorders are a group of signs, symptoms and several syndromes, extremely prevalent and that occur in different age groups (from newborn to elderly). The amount of knowledge regarding sleep mechanisms and sleep disorders has significantly increased in recent years as well as new therapeutic options have been proposed. However, most Medical Schools do not include the study of Sleep in their curriculum. This course is fully justified by its profile to multidisciplinary graduate program as ours. |
| Professors | Home time | Lattes |
| MAGDA LAHORGUE NUNES | 33 years and 8 months | Link |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 1933H-02 | 30 | The course aims to provide a comprehensive overview of the principles of vaccination, general recommendations, adverse effects and information on immune-preventable diseases. In addition, to providing information on the technologies currently used for the production of vaccines available on the market and the new technologies studied for vaccines under development Goals: Train the student to general and specific knowledge of vaccine production already used. To train the student as to the critical sense to the new vaccines under development. Content: General aspects of the immune response to vaccines, vaccines currently used, vaccine production technology, new vaccines studied. |
| Professors | Home time | Lattes |
| ANA PAULA DUARTE DE SOUZA | 11 years and 8 months | Link |
| MARCELO COMERLATO SCOTTA | 13 years and 4 months | Link |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |
| COD | Workload | Description |
| 1933E-01 | 15 |
| No offer for current semester |
| Concentration area | Type | Required |
| Pediatrics | Master's | Not required |
| Pediatrics | Doctorate | Not required |
| Research line | Description |